Abilify også til mennesker med bipolar lidelse...

Er der et bedre medicinsk alternativ end Abilify


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Cornelius Christiansen

webmaster
Sidefrivillig
I USA er det nu endeligt muligt med, Abilify, som præparat imod bipolar lidelse. Jeg er normalt meget skeptisk overfor det meste medicin, men jeg synes nu godt om mit liv med abilify. Det er et glimrende - drug - imod psykotiske symptomer og mange andre eksempelvis lidelser som - mani depressivitet.

Jeg så denne artikel og ville lige dele:

https://borsen.dk/nyheder/virksomheder/artikel/1/348779/lundbeck_faar_fda-godkendelse_til_brug_af_abilify_til_bipolaere.html

Hvor det fremgår; at man nu også i USA vil bruge et ikke oralt men "depot" altså sprøjte produkt bi polar lidelse. Jeg synes man bør tale om de egentlige bivirkninger! Jeg får kramper og har svært visee fysske udfoldeleser, som kraftig motion eller nogle kropslige stræk.
Jeg vil gerne også være fortaler for lysentin, der virker krampenedsættende. Den kunne jeg ikke undvære + jeg ville gerne være mindre hyper og have lettrere ved at sove.

Se også:

https://pro.medicin.dk/Medicin/Praeparater/3380
 

Cornelius Christiansen

webmaster
Sidefrivillig
Grundlæggende er - en psykose tilstand - en sygdom der rammer hjernen med negativ udvikling i neurotransmitorende. Det er muligt for Abilify at aktiverer nogle synapser og deaktiverer andre. Her er en lille illustration af dette forklaret let og ellegant...


Yeah det forklarer det
 

Lars

Administrator
Abilify er et varemærke.

7-{4-[4-(2,3-dichlorphenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-on

Hvad er så Abilify?


OK, Abilify er det som også hedder Aripiprazol(e), som er medicin navnet.

Hvad er piperazine for noget, så?


Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
Piperazines were originally named because of their chemical similarity with piperidine, part of the structure of piperine in the black pepper plant (Piper nigrum). It is important to note, however, that piperazines are not derived from plants in the Piper genus.

Interessant.

Many currently notable drugs contain a piperazine ring as part of their molecular structure. Examples include:

Antianginals

Ranolazine
Trimetazidine

Antidepressants

Amoxapine
Befuraline
Buspirone
Flesinoxan
Gepirone
Ipsapirone
Nefazodone
Piberaline
Tandospirone
Trazodone
Vilazodone
Zalospirone
Vortioxetine

Antihistamines

Buclizine
Meclizine
Cinnarizine
Cyclizine
Hydroxyzine
Cetirizine
Levocetirizine
Niaprazine

Antiserotonergics

EGIS-7625

Antipsychotics

Typical
Fluphenazine
Perphenazine
Trifluoperazine
Prochlorperazine
Thiothixene
Flupentixol
Zuclopenthixol
Atypical
Amperozide
Aripiprazole
Lurasidone
Clozapine
Olanzapine
Perospirone
Ziprasidone

Recreational Drugs

4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP)
1-Benzylpiperazine (BZP)
2,3-Dichlorophenylpiperazine (DCPP)
1,4-Dibenzylpiperazine (DBZP)
4-Methyl-1-benzylpiperazine (MBZP)
3-Chlorophenylpiperazine (mCPP)
3,4-Methylenedioxy-1-benzylpiperazine (MDBZP)
4-Methoxyphenylpiperazine (MeOPP)
Methoxypiperamide (MeOP or MEXP)
4-Chlorophenylpiperazine (pCPP)
4-Fluorophenylpiperazine (pFPP)
3-Trifluoromethylphenylpiperazine (TFMPP)

Urologicals

Sildenafil
Vardenafil

Others

6-Nitroquipazine
Antrafenine
Fipexide
Imatinib
NSI-189
Piperazine (itself)
Quipazine
Tolpiprazole (tranquilizer)
Diphenazin
Piposulfan (Antineoplastic agent, aquatic herbicide.)
Sunifiram (Nootropic)

Most of these agents can be classified as either phenylpiperazines, benzylpiperazines, diphenylmethylpiperazines (benzhydrylpiperazines), pyridinylpiperazines, pyrimidinylpiperazines, or tricyclics (with the piperazine ring attached to the heterocyclic moiety via a side chain).

Ahaaaa!!
 

Lars

Administrator
Ari

Greek Meaning:

The name Ari is a Greek baby name. In Greek the meaning of the name Ari is: Superior; best of thinkers. Famous Bearers: ancient Greek philosopher Aristotle, and Greek shipping tycoon Aristotle Onassis.
Hebrew Meaning:

The name Ari is a Hebrew baby name. In Hebrew the meaning of the name Ari is: Lion.
Maori Meaning:

The name Ari is a Maori baby name. In Maori the meaning of the name Ari is: Visible and clear.
Norse Meaning:

The name Ari is a Norse baby name. In Norse the meaning of the name Ari is: Eagle.
American Meaning:

The name Ari is an American baby name. In American the meaning of the name Ari is: Eagle.
 

Lars

Administrator
Kun til videre forståelse: https://en.m.wikipedia.org/wiki/Recreational_drug_use

The following substances are used recreationally:[24]

Alcohol: Most drinking alcohol is ethanol, CH
3CH
2OH. Drinking alcohol creates intoxication, relaxation and lowered inhibitions. It is produced by the fermentation of sugars by yeasts to create wine, beer, and distilled liquor (e.g., vodka, rum, gin, etc.). In most areas of the world, apart from certain countries where Muslim sharia law is used, it is legal for those over a certain age (18 in most countries). It is an IARC 'Group 1' carcinogen and a teratogen.[25] Alcohol withdrawal can be life-threatening.[26]
Amphetamines: Used recreationally to provide alertness and a sense of energy. Prescribed for ADHD, narcolepsy, depression and weight loss. A potent central nervous system stimulant, in the 1940s and 50s methamphetamine was used by Axis and Allied troops in World War II, and, later on, other armies, and by Japanese factory workers. It increases muscle strength and fatigue resistance and improves reaction time.[27] Methamphetamine use can be neurotoxic, which means it damages dopamine neurons.[28] As a result of this brain damage, chronic use can lead to post acute withdrawal syndrome.[29]
Caffeine: Often found in coffee, black tea, energy drinks, some soft drinks (e.g., Coca-Cola, Pepsi and Mountain Dew, among others), and chocolate. It is the world's most widely consumed psychoactive drug, it has no dependence liability.
Cannabis: Its common forms include marijuana and hashish, which are smoked or eaten. It contains at least 85 cannabinoids. The primary psychoactive component is THC, which mimics the neurotransmitter anandamide, named after the Hindu ananda, "joy, bliss, delight." The review article Campbell & Gowran (2007) states that "manipulation of the cannabinoid system offers the potential to upregulate neuroprotective mechanisms while dampening neuroinflammation. Whether these properties will be beneficial in the treatment of Alzheimer's disease in the future is an exciting topic that undoubtedly warrants further investigation."
Cocaine: It is available as a white powder, which is insufflated ("sniffed" into the nostrils) or converted into a solution with water and injected. A popular derivative, crack cocaine is typically smoked. When transformed into its freebase form, crack, the cocaine vapour may be inhaled directly. This is thought to increase bioavailability, but has also been found to be toxic, due to the production of methylecgonidine during pyrolysis.[30][31][32]
MDMA: Commonly known as ecstasy, it is a common club drug in the rave scene.
Electronic cigarette: A large proportion of e-cigarette use is recreational.[33] Most e-cigarette liquids contain nicotine, but the level of nicotine varies depending on user-preference and manufacturers.[34] Nicotine is highly addictive,[35][36][37] comparable to heroin or cocaine.[38] Some people have also used to e cigarette to smoke cannabis or other drugs and there are certain e cigarettes specifically made for the use of smoking liquid cannabis.
Ketamine: An anesthetic used legally by paramedics and doctors in emergency situations for its dissociative and analgesic qualities and illegally in the club drug scene.
LSD: A popular ergoline derivative, that was first synthesized in 1938 by Hofmann. However, he failed to notice its psychedelic potential until 1943.[39] In the 1950s, it was used in psychological therapy, and, covertly, by the CIA in Project MKULTRA, in which the drug was administered to unwitting US and Canadian citizens. It played a central role in 1960s 'counter-culture', and was banned in October 1968 by US President Lyndon B Johnson.[40][41]
Nitrous oxide: legally used by dentists as an anxiolytic and anaesthetic, it is also used recreationally by users who obtain it from whipped cream canisters (whippets or whip-its) (see inhalant), as it causes perceptual effects, a "high" and at higher doses, hallucinations.
Opiates and opioids: Available by prescription for pain relief. Commonly abused opioids include oxycodone, hydrocodone, codeine, fentanyl, heroin, and morphine. Opioids have a high potential for addiction and have the ability to induce severe physical withdrawal symptoms upon cessation of frequent use. Heroin can be smoked, insufflated or turned into a solution with water and injected.
Psilocybin mushrooms: This hallucinogenic drug was an important drug in the psychedelic scene. Until 1963, when it was chemically analysed by Albert Hofmann, it was completely unknown to modern science that Psilocybe semilanceata ("Liberty Cap", common throughout Europe) contains psilocybin, a hallucinogen previously identified only in species native to Mexico, Asia, and North America.[42]
Tobacco: Nicotiana tabacum. Nicotine is the key drug contained in tobacco leaves, which are either smoked, chewed or snuffed. It contains nicotine, which crosses the blood–brain barrier in 10–20 seconds. It mimics the action of the neurotransmitter acetylcholine at nicotinic acetylcholine receptors in the brain and the neuromuscular junction. The neuronal forms of the receptor are present both post-synaptically (involved in classical neurotransmission) and pre-synaptically, where they can influence the release of multiple neurotransmitters.[43]
Tranquilizers: barbiturates, benzodiazepines (commonly prescribed for anxiety disorders; known to cause dementia and post acute withdrawal syndrome)
"Bath salts": this is the street name for Mephedrone/Methylenedioxypyrovalerone (MDPV)
DMT – primary ingredient in ayahuasca, can also be smoked in a crack pipe; briefly (c. 30 minutes) causes a "total loss of connection to external reality"[44]
Peyote: This hallucinogen contains mescaline, native to southwestern Texas and Mexico
Salvia divinorum: This hallucinogenic Mexican herb in the mint family; not considered recreational, most likely due to the nature of the hallucinations (legal in some jurisdictions)
Synthetic cannabis: "Spice", "K2", JWH-018, AM-2201
Research chemicals: 2C variants, etc.

Depressants
Edit

Depressants are psychoactive drugs that temporarily diminish the function or activity of a specific part of the body or mind.[46] Colloquially, depressants are known as "downers", and users generally take them to feel more relaxed and less tense. Examples of these kinds of effects may include anxiolysis, sedation, and hypotension. Depressants are widely used throughout the world as prescription medicines and as illicit substances. When these are used, effects may include anxiolysis (reduction of anxiety), analgesia (pain relief), sedation, somnolence, cognitive/memory impairment, dissociation, muscle relaxation, lowered blood pressure/heart rate, respiratory depression, anesthesia, and anticonvulsant effects. Depressants exert their effects through a number of different pharmacological mechanisms, the most prominent of which include facilitation of GABA or opioid activity, and inhibition of adrenergic, histamine or acetylcholine activity. Some are also capable of inducing feelings of euphoria (a happy sensation). The most widely used depressant by far is alcohol.

Stimulants or "uppers", such as amphetamines or cocaine, which increase mental or physical function, have an opposite effect to depressants.
Antihistamines
Edit

Antihistamines (or "histamine antagonists") inhibit the release or action of histamine. "Antihistamine" can be used to describe any histamine antagonist, but the term is usually reserved for the classical antihistamines that act upon the H1 histamine receptor. Antihistamines are used as treatment for allergies. Allergies are caused by an excessive response of the body to allergens, such as the pollen released by grasses and trees. An allergic reaction causes release of histamine by the body. Other uses of antihistamines are to help with normal symptoms of insect stings even if there is no allergic reaction. Their recreational appeal exists mainly due to their anticholinergic properties, that induce anxiolysis and, in some cases such as diphenhydramine, chlorpheniramine, and orphenadrine, a characteristic euphoria at moderate doses. High dosages taken to induce recreational drug effects may lead to overdoses. Antihistamines are also consumed in combination with alcohol, particularly by youth who find it hard to obtain alcohol. The combination of the two drugs can cause intoxication with lower alcohol doses.

Hallucinations and possibly delirium resembling the effects of Datura stramonium can result if the drug is taken in much higher than therapeutical dosages. Antihistamines are widely available over the counter at drug stores (without a prescription), in the form of allergy medication and some cough medicines. They are sometimes used in combination with other substances such as alcohol. The most common unsupervised use of antihistamines in terms of volume and percentage of the total is perhaps in parallel to the medicinal use of some antihistamines to stretch out and intensify the effects of opioids and depressants. The most commonly used are hydroxyzine, mainly to stretch out a supply of other drugs, as in medical use, and the above-mentioned ethanolamine and alkylamine-class first-generation antihistamines, which are - once again as in the 1950s - the subject of medical research into their anti-depressant properties.

For all of the above reasons, the use of medicinal scopolamine for recreational uses is also seen.
Analgesics
Edit

Analgesics (also known as "painkillers") are used to relieve pain (achieve analgesia). The word analgesic derives from Greek "αν-" (an-, "without") and "άλγος" (álgos, "pain"). Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (para-acetylaminophenol, also known in the US as acetaminophen), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as hydrocodone, codeine, heroin and oxycodone. Some further examples of the brand name prescription opiates and opioid analgesics that may be used recreationally include Vicodin, Lortab, Norco (hydrocodone), Avinza, Kapanol (morphine), Opana, Paramorphan (oxymorphone), Dilaudid, Palladone (hydromorphone), and OxyContin (oxycodone).
Tranquilizers
Edit

Tranquilizers (GABAergics):

Barbiturates
Benzodiazepines
Ethanol (drinking alcohol; ethyl alcohol)
Nonbenzodiazepines
Others
carisoprodol (Soma)
chloral hydrate
diethyl ether
ethchlorvynol (Placidyl; "jelly-bellies")
gamma-butyrolactone (GBL, a prodrug to GHB)
gamma-hydroxybutyrate (GHB; G; Xyrem; "Liquid Ecstasy", "Fantasy")
glutethimide (Doriden)
kava (from Piper methysticum; contains kavalactones)
ketamine
meprobamate (Miltown)
methaqualone (Sopor, Mandrax; "Quaaludes")
phenibut
propofol (Diprivan)
theanine (found in Camellia sinensis, the tea plant)
valerian (from Valeriana officinalis)

Således, nu er stafeten givet videre
 

Lars

Administrator

Amperozide

Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor.[1] It does not block dopamine receptors as with most antipsychotic drugs,[2] but does inhibit dopamine release,[3][4] and alters the firing pattern of dopaminergic neurons.[5] It was investigated for the treatment of schizophrenia in humans,[6] but never adopted clinically. Its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity.[7][8][9]
 
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